abstract：:Dendritic cells (DCs) are the most potent specialized antigen-presenting cells as now known, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Immunologically, the motilities and T cell activation capabilities of DCs are closely related to the resulting immune respon...

journal_title：International journal of biological sciences

authors： Huang WZ,Hu WH,Wang Y,Chen J,Hu ZQ,Zhou J,Liu L,Qiu W,Tang FZ,Zhang SC,Ouyang Y,Ye YN,Xu GQ,Long JH,Zeng Z

更新日期：2019-05-20 00:00:00

abstract：:Background: The preoperative controlling nutritional status (CONUT) score and circulating tumour cell (CTC) status are associated with poor prognosis of colorectal cancer (CRC). The aim of the present study is to determine whether the combination of CONUT and CTC (CONUT-CTC) could better predict the prognosis of CRC p...

journal_title：International journal of biological sciences

authors： Yang C,Wei C,Wang S,Han S,Shi D,Zhang C,Lin X,Dou R,Xiong B

更新日期：2019-05-12 00:00:00

abstract：:Despite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on the rise throughout the world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes in patients with cancer,...

journal_title：International journal of biological sciences

authors： Wang M,Jiang S,Zhou L,Yu F,Ding H,Li P,Zhou M,Wang K

更新日期：2019-05-07 00:00:00

abstract：:With the advancement of nanotechnology, various nanocomposites have been applied in the diagnostics and treatment of cancer. We synthetized FePt nanoparticles which were assembled on the surface of graphene oxide (GO). These novel FePt/GO nanosheets simultaneously act as a chemotherapy drug and enhance radiosensitivit...

journal_title：International journal of biological sciences

authors： Ma S,Miao H,Luo Y,Sun Y,Tian X,Wang F,You C,Peng S,Tang G,Yang C,Sun W,Li S,Mao Y,Xu J,Xiao Y,Gong Y,Quan H,Xie C

更新日期：2019-03-10 00:00:00

abstract：:Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is involved in the prevention of hepatotoxicity. The purpose of the current study was to explore the protective effect of farrerol against acetaminophen-induced hepatotoxicity and its underlying mechanisms. Mice were used to eva...

journal_title：International journal of biological sciences

authors： Wang L,Wei W,Xiao Q,Yang H,Ci X

更新日期：2019-01-29 00:00:00

abstract：:Reverting activated hepatic stellate cells (HSCs) to less activation or quiescent status is a promising strategy for liver fibrosis. Histone deacetylase inhibitor (HDACI) could suppress HSCs activation. Our previous study demonstrated a critical role of miRNAs in HSCs activation. Here, we explored the involvement of m...

journal_title：International journal of biological sciences

authors： Lu P,Yan M,He L,Li J,Ji Y,Ji J

更新日期：2019-01-06 00:00:00

abstract：:Endoplasmic reticulum (ER) stress-induced neuronal apoptosis is a crucial pathological process of spinal cord injury (SCI). In our previous study, icariin (ICA) showed neuroprotective effects in SCI. However, the relationships between ER stress and ICA in SCI are unclear yet. Therefore, whether ICA could ameliorate SC...

journal_title：International journal of biological sciences

authors： Li H,Zhang X,Qi X,Zhu X,Cheng L

更新日期：2019-01-01 00:00:00

abstract：:Melatonin is present in mammalian follicular fluid and plays an important role in regulating steroidogenesis in follicular cells. In this study, we report the effect of melatonin on steroidogenesis in the theca interna (TI) in small bovine follicles and theca cells (TCs) cultured in vitro. Treatment with melatonin sig...

journal_title：International journal of biological sciences

authors： Wang X,Meng K,He Y,Wang H,Zhang Y,Quan F

更新日期：2019-01-01 00:00:00

abstract：:Glioma is one of the most common brain tumors, suggesting the importance of investigating the molecular mechanism of gliomas. We studied the roles of Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in glioma. Expressions of RRM2 are higher in glioma tissues evidenced by TCGA data, western blot and immunohistoche...

journal_title：International journal of biological sciences

authors： Sun H,Yang B,Zhang H,Song J,Zhang Y,Xing J,Yang Z,Wei C,Xu T,Yu Z,Xu Z,Hou M,Ji M,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elu...

journal_title：International journal of biological sciences

authors： Liu F,Xia Z,Zhang M,Ding J,Feng Y,Wu J,Dong Y,Gao W,Han Z,Liu Y,Yao Y,Li D

更新日期：2019-01-01 00:00:00

abstract：:We collected clinical data from 308 prostate cancer (PCa) patients to investigate the clinical characteristics and independent risk factors of bone metastasis (BM) and to establish a prediction model for BM of PCa and determine the necessity of bone scans. Univariate and multivariate analyses were performed based on a...

journal_title：International journal of biological sciences

authors： Chen S,Wang L,Qian K,Jiang W,Deng H,Zhou Q,Wang G,Liu X,Wu CL,Xiao Y,Wang X

更新日期：2019-01-01 00:00:00

abstract：:Ovarian cancer is the fifth common cause of death in woman worldwide. The tripartite motif-containing (TRIM) proteins consist of more than 70 known protein members. Studies have showed that TRIM proteins are involved in cancer and play important roles in cancer cell proliferation, migration, adhesion and metastasis. R...

journal_title：International journal of biological sciences

authors： Wang Y,Zhou Z,Wang X,Zhang X,Chen Y,Bai J,Di W

更新日期：2018-11-03 00:00:00

abstract：:Exosomes mediate cell-cell crosstalk in cancer progression by transferring their molecular cargos, including long noncoding RNAs (lncRNAs). Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a well-known lncRNA associated with cancer angiogenesis and metastasis. However, the presence of MALAT1 in exoso...

journal_title：International journal of biological sciences

authors： Qiu JJ,Lin XJ,Tang XY,Zheng TT,Lin YY,Hua KQ

更新日期：2018-11-01 00:00:00

abstract：:Mitochondrial dysfunction is an important contributor to the development of osteoarthritis (OA). Sirtuin 3 (SIRT3) regulates diverse mitochondrial proteins to maintain mitochondrial homeostasis, and dihydromyricetin (DHM) is reported as a potential SIRT3 activator. This study aims to explore the relevance of SIRT3 and...

journal_title：International journal of biological sciences

authors： Wang J,Wang K,Huang C,Lin D,Zhou Y,Wu Y,Tian N,Fan P,Pan X,Xu D,Hu J,Zhou Y,Wang X,Zhang X

更新日期：2018-10-20 00:00:00

abstract：:BRCA1-deficient breast cancer is a very well-known hereditary cancer. However, except for resection of normal mammary glands and ovaries, there is no acceptable measure for proactively preventing tumor development. Importantly, inherited BRCA1 mutations are closely associated with tumors in hormone-responsive tissues....

journal_title：International journal of biological sciences

authors： Baek HJ,Kim SE,Choi EK,Kim JK,Shin DH,Park EJ,Kim TH,Kim JY,Kim KG,Deng CX,Kim SS

更新日期：2018-10-03 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) occurs with the highest frequency in China, especially in the high-risk Northern Chinese. Recent studies have reported that SLC22A3 is significantly downregulated in non-tumor (NT) esophageal tissues from familial ESCC patients compared with those from sporadic ESCC. However, ...

journal_title：International journal of biological sciences

authors： Xiong JX,Wang YS,Sheng J,Xiang D,Huang TX,Tan BB,Zeng CM,Li HH,Yang J,Meltzer SJ,Mori Y,Qin YR,Guan XY,Fu L

更新日期：2018-09-07 00:00:00

abstract：:By introduction of Oct4, Sox2, Klf4 and cMyc, human adult somatic cells can be reprogrammed into embryonic stem cell capable of pluripotent differentiation. In several lines of human endometrial polyp- and cervical polyp-mesenchymal stem cells (EPMSCs and CPMSC), we showed introduction of the four transcription factor...

journal_title：International journal of biological sciences

authors： Ding DC,Chu TY,Liu HW

更新日期：2018-09-07 00:00:00

abstract：:Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple organs and are characterized by hyperglycaemia. Currently, stable and effective treatments for obesity and type 2 diabetes mellitus are not available. Therefore, the mechanisms leading to obesity and diabetes and more effectiv...

journal_title：International journal of biological sciences

authors： Huang X,Liu G,Guo J,Su Z

更新日期：2018-08-06 00:00:00

abstract：:Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...

journal_title：International journal of biological sciences

authors： Sha M,Jeong S,Chen XS,Tong Y,Cao J,Sun HY,Xia L,Xu N,Wang X,Han LZ,Xi ZF,Zhang JJ,Kong XN,Xia Q

更新日期：2018-07-27 00:00:00

abstract：:Infectious HCV carrying reporter genes have further applications in understanding the HCV life cycle including replication, viral assembly and release. In this study, a full-length 3039bp LacZ gene was inserted into the derivative of JFH1-AM120 to develop an additional reporter virus. The results showed that the recom...

journal_title：International journal of biological sciences

authors： Wang Q,Hagedorn C,Liu S

更新日期：2018-07-13 00:00:00

abstract：:Structural maintenance of chromosomes protein 1A (SMC1A) has been implicated in the development of a variety of cancer types. However, its role in hepatocellular carcinoma remains unknown. In this study, we found that phosphorylated SMC1A was highly expressed in HepG2 and Bel7402 cells when compared with other cancer ...

journal_title：International journal of biological sciences

authors： Zhang Y,Yi F,Wang L,Wang Z,Zhang N,Wang Z,Li Z,Song X,Wei S,Cao L

更新日期：2018-06-08 00:00:00

abstract：:Clinical evidence suggests that there exists a strong correlation between Zika virus (ZIKV) infection and abnormal development of the nervous system. However, the underlying mechanisms remain to be elusive. In this study, recombinant lentiviral vectors coding for ZIKV structural proteins and truncations (prM-Env, M-En...

journal_title：International journal of biological sciences

authors： Liu J,Li Q,Li X,Qiu Z,Li A,Liang W,Chen H,Cai X,Chen X,Duan X,Li J,Wu W,Xu M,Mao Y,Chen H,Li J,Gu W,Li H

更新日期：2018-06-08 00:00:00

abstract：:Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...

journal_title：International journal of biological sciences

authors： Chen J,Ma L,Zhang N,Zhu Y,Zhang K,Xu Z,Wang Q

更新日期：2018-06-03 00:00:00

abstract：:It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. But the weakly differential expression signals between two phenotypes are hardly detectable with limited sample sizes. To solve this problem, many researchers tried to combi...

journal_title：International journal of biological sciences

authors： Cai H,Li X,Li J,Liang Q,Zheng W,Guan Q,Guo Z,Wang X

更新日期：2018-05-22 00:00:00

abstract：:Non-coding RNAs (ncRNAs) are transcribed from genome but not translated into proteins. Many ncRNAs are key regulators of plants growth and development, metabolism and stress tolerance. In order to make the web-based ncRNA resources for plant science research be more easily accessible and understandable, we made a comp...

journal_title：International journal of biological sciences

authors： Liao P,Li S,Cui X,Zheng Y

更新日期：2018-05-22 00:00:00

abstract：:The insulin-like growth factors (IGFs), IGF-I and IGF-II, are essential for regulating cell growth, differentiation and metastasis of a broad range of malignancies. The IGF-I/II actions are mediated through the IGF receptor type 1 (IGF-1R) and the insulin receptor (IR), which are overexpressed in multiple types of tum...

journal_title：International journal of biological sciences

authors： Chen Z,Liu J,Chu D,Shan Y,Ma G,Zhang H,Zhang XD,Wang P,Chen Q,Deng C,Chen W,Dimitrov DS,Zhao Q

更新日期：2018-05-21 00:00:00

abstract：:Cell-matrix interactions play critical roles in cell adhesion, tissue remodeling and cancer metastasis. Discoidin domain receptor 2 (DDR2) is a collagen receptor belonging to receptor tyrosine kinase (RTK) family. It is a powerful regulator of collagen deposition in the extracellular matrix (ECM). Although the oligome...

journal_title：International journal of biological sciences

authors： Li T,Liu J,Cai H,Wang B,Feng Y,Liu J

更新日期：2018-04-30 00:00:00

abstract：:The mineralization-front theory is historically rooted in mineralization research fields for many decades. This theory is widely used to describe mineralization events in both osteogenesis and dentinogenesis. However, this model does not provide enough evidence to explain how minerals are propagated from the pulp-end ...

journal_title：International journal of biological sciences

authors： Li C,Jing Y,Wang K,Ren Y,Liu X,Wang X,Wang Z,Zhao H,Feng JQ

更新日期：2018-04-30 00:00:00

abstract：:Cell density has profound impacts on the cell culture practices of human pluripotent stem cells. The regulation of cell growth, cell death, pluripotency and differentiation converge at high density, but it is largely unknown how different regulatory mechanisms act at this stage. We use a chemically defined medium to s...

journal_title：International journal of biological sciences

authors： Liu W,Ren Z,Lu K,Song C,Cheung ECW,Zhou Z,Chen G

更新日期：2018-04-05 00:00:00

abstract：BACKGROUND & OBJECTIVE:The incidence of non-small cell lung cancer (NSCLC) has been rising over the past several decades. Despite various therapeutic regimens and modern diagnostic techniques are developed, NSCLC still have an extremely poor prognosis due to drug resistance. Therefore, it is critical to find a novel pr...

journal_title：International journal of biological sciences

authors： Lu J,Zhan Y,Feng J,Luo J,Fan S

更新日期：2018-03-10 00:00:00

abstract：:When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...

journal_title：International journal of biological sciences

authors： Senju H,Kumagai A,Nakamura Y,Yamaguchi H,Nakatomi K,Fukami S,Shiraishi K,Harada Y,Nakamura M,Okamura H,Tanaka Y,Mukae H

更新日期：2018-03-09 00:00:00

abstract：:Breast cancer (BC) is the most common cause of death in women throughout the world. Although microRNAs (miRNAs) have been identified as novel regulators in carcinogenesis, there are still abundant hidden treasure needed to be excavated. In the present study, we found that miR-519d expression was remarkably decreased i...

journal_title：International journal of biological sciences

authors： Chu C,Liu X,Bai X,Zhao T,Wang M,Xu R,Li M,Hu Y,Li W,Yang L,Qin Y,Yang M,Yan C,Zhang Y

更新日期：2018-02-09 00:00:00

abstract：:Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression. SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inactivated in over half...

journal_title：International journal of biological sciences

authors： Zhao M,Mishra L,Deng CX

更新日期：2018-01-12 00:00:00

abstract：:A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process inste...

journal_title：International journal of biological sciences

authors： Jing Y,Jing J,Wang K,Chan K,Harris SE,Hinton RJ,Feng JQ

更新日期：2018-01-01 00:00:00

abstract：:After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary ...

journal_title：International journal of biological sciences

authors： Zheng B,Zhou Y,Zhang H,Yang G,Hong Z,Han D,Wang Q,He Z,Liu Y,Wu F,Zhang X,Tong S,Xu H,Xiao J

更新日期：2017-11-27 00:00:00

abstract：:Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but...

journal_title：International journal of biological sciences

authors： Liu X,Su P,Meng S,Aschner M,Cao Y,Luo W,Zheng G,Liu M

更新日期：2017-10-31 00:00:00

abstract：:β2-Adrenoceptor (β2-AR) agonists promote muscle growth. The aim of this study was to elucidate some effects of the selective β2-adrenoceptor agonist clenbuterol (CLB) on myoblast proliferation. We found that CLB induces cell cycle arrest in C2C12 myoblasts. This effect is partly due to the enhanced stability of p27, r...

journal_title：International journal of biological sciences

authors： Chen M,Liu C,Wang M,Wang H,Zhang K,Zheng Y,Yu Z,Li X,Guo W,Li N,Meng Q

更新日期：2017-10-17 00:00:00

abstract：:Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC). Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were en...

journal_title：International journal of biological sciences

authors： Jeong S,Zheng B,Wang J,Chi J,Tong Y,Xia L,Xu N,Zhang J,Kong X,Gu J,Xia Q

更新日期：2017-09-21 00:00:00

abstract：:Background: To compare the risk of type 2 diabetes (T2DM) between patients with and without chronic osteomyelitis (COM), both in humans and in mice, and to explore risk factors in COM patients who developed T2DM. Methods: One hundred seven patients with COM and 114 patients without COM were consecutively enrolled and ...

journal_title：International journal of biological sciences

authors： Wang Y,Wang J,Deng Z,Jin J,Jiang H,Meng J,Xu H,Zhao J,Sun G,Qian H

更新日期：2017-09-05 00:00:00

abstract：:Type 2 diabetes mellitus is characterized by insulin resistance. However, the complete molecular mechanism remains unclear. In this study, zebrafish were fed a long-term high-fat diet to induce type 2 diabetes, which resulted in a higher body weight, body mass index, more lipid vacuoles in liver, increased insulin tra...

journal_title：International journal of biological sciences

authors： Meng XH,Chen B,Zhang JP

更新日期：2017-07-18 00:00:00